A long night on the graveyard shift proves difficult for Dr. Reese. Meanwhile, April gets called in to work and is pressured to slow down by Tate; Dr. Charles passes along vital news; and Dr. Rhodes must operate on a mystery patient.
Maggie must face her past when her arresting officer arrives at the hospital with a serious injury. Also, a heart transplant patient gets into a car crash, complicating her surgery; Dr. Halstead treats an uncooperative horse jockey; Manning and Halstead deal with a patient’s death.
Dr. Halstead and Dr. Manning deal with two warring brothers who are brought together when one finds himself in desperate need of a kidney. Dr. Reese’s former patient Danny comes to a crossroad. Dr. Rhodes and Dr. Latham treat a 16-year-old girl with a genetic condition in need of surgery, but whose overprotective mother disagrees with that course of action. A convict with unusual intentions puts himself in the hospital and Dr. Charles meddles in his daughter Robyn’s personal life, much to her dismay. Meanwhile, Dr. Halstead and April make a discovery that complicates her treatment for TB.